Various sources highlight the limited therapeutic index of pure THC, when given intravenously (D’Souza et al., 2004) orally (Favrat et al., 2005), especially in people previously naïve to its effects. Acute overdose incidents involving THC or THC-predominant cannabis usually consist of self-limited panic reactions or toxic psychoses, for which no pharmacological intervention is generally necessary, and supportive counselling (reassurance or ‘talking down’) is sufficient to allow resolution without sequelae. CBD modulates the psy- choactivity of THC and reduces its adverse event profile (Russo and Guy, 2006), highlighted by recent results above described. Could it be, however, that other cannabis components offer additional attenuation of the less undesirable effects of THC? History provides some clues.
This is an inspiring summary and the quoted phrase below is so exciting!
"......further research of the entourage effect in this versatile plant that may help it fulfil its promise as a pharmacological treasure trove" Respect and thanks to the author.
This is an inspiring summary and the quoted phrase below is so exciting!
"......further research of the entourage effect in this versatile plant that may help it fulfil its promise as a pharmacological treasure trove" Respect and thanks to the author.